Topic: Nigrostriatal dopamine pathway regulates auditory behaviors
Speaker: Associate Professor XIONG Qiaojie, Department of Neurobiology and Behavior, State University of New York at Stony Brook (SBU)
Date and time: 10:00–11:30, January 26
Venue: Tencent Meeting
Meeting ID: 846 953 135
Host: YANG Yang
Abstract:
The auditory striatum, the tail portion of dorsal striatum in basal ganglia, is implicated in perceptual decision-making, transforming auditory stimuli to action outcomes. Despite its known connections to diverse neurological conditions, the dopaminergic modulation of sensory striatal neuronal activity and its behavioral influences remain unknown. We use mouse model to delineate the roles of nigrostriatal dopamine in sensory-guided behaviors and the underlying circuit mechanisms. Using in vivo Ca2+ imaging and opto-/chemo-genetic approaches, we demonstrated that the midbrain dopaminergic projections to the auditory striatum actively modulate sensory coding during reinforcement learning and decision-making.
Biography:
Associate Professor, Department of Neurobiology and Behavior, SUNY Stony Brook (2021–present)
Assistant Professor, Department of Neurobiology and Behavior, SUNY Stony Brook (2015–2021)
Postdoctoral fellow, Cold Spring Harbor Laboratory (2008–2015)
PhD, Department of Physiology, Johns Hopkins University (2008)